Réponses Moléculaires et Cellulaires aux Xénobiotiques (RMCX)


Sélection de publications

1/ Sanchez-Guzman D., Boland S., Brookes O., Mc Cord C., Lai Kuen R., Sirri V., Baeza Squiban A.*, Devineau S.* Long-term evolution of the epithelial cell secretome in preclinical 3D models of the human bronchial epithelium. Sci Rep. 2021, 11:6621

2/ Brookes O., Boland S., Lai Kuen R., Movassat J., Baeza-Squiban A. Co-culture of type I and type II pneumocytes as a model of alveolar epithelium, Plos One. 2021 Sep 27;16(9):e0248798.

3/ Berthelet J, Michail C, Bui LC, Le Coadou L, Sirri V, Wang L, Dulphy N, Dupret JM, Chomienne C, Guidez F, Rodrigues-Lima F. The Benzene Hematotoxic and Reactive Metabolite 1,4-Benzoquinone Impairs the Activity of the Histone Methyltransferase SET Domain Containing 2 (SETD2) and Causes Aberrant Histone H3 Lysine 36 Trimethylation (H3K36me3). Mol Pharmacol. 2021 Sep;100(3):283-294.

4/ Duval R, Bui LC, Mathieu C, Nian Q, Berthelet J, Xu X, Haddad I, Vinh J, Dupret JM, Busi F, Guidez F, Chomienne C, Rodrigues-Lima F. Benzoquinone, a leukemogenic metabolite of benzene, catalytically inhibits the protein tyrosine phosphatase PTPN2 and alters STAT1 signaling. J Biol Chem. 2019 Aug 16;294(33):12483-12494.

5/ Mathieu C, Duval R, Cocaign A, Petit E, Bui LC, Haddad I, Vinh J, Etchebest C, Dupret JM, Rodrigues Lima F. An isozyme-specific redox switch in human brain glycogen phosphorylase modulates its allosteric activation by AMP. J Biol Chem. 2016 Sept 22. “Paper of the Week” of the Journal of Biological Chemistry


Publications dans des journaux à comité de lecture (depuis 2017)

** Publications communes avec d’autres équipes de BFA.

Quartile (Scimago Journal & Country Rank) indiqué à la fin de chaque référence.


Original articles




Le Coadou L, Berthelet J, Mechaly AE, Michail C, Bui LC, Dairou J, Haouz A, Dupret JM, Rodrigues Lima F. Structural and enzymatic evidence for the methylation of the ACK1 tyrosine kinase by the histone lysine methyltransferase SETD2. Biochem Biophys Res Commun. 2024 Feb 5;695:149400. (Q2)


Zhou Q, Zhang J, Zhang J, Liang S, Cai D, Xiao H, Zhu Y, Xiang W, Rodrigues- Lima F, Chi J, Guidez F, Wang L. Vemurafenib induces senescence in acute myeloid leukemia and myelodysplastic syndrome by activating the HIPPO signaling pathway: implications for potential targeted therapy. Biol Direct. 2024 Jan 4;19(1):6. (Q1)


** Delabar JM, Gomes MAGB, Fructuoso M, Sarrazin N, George N, Fleary-Roberts N, Sun H, Bui LC, Rodrigues-Lima F, Janel N, Dairou J, Maria EJ, Dodd RH, Cariou K, Potier MC. EGCG-like non-competitive inhibitor of DYRK1A rescues cognitive defect in a down syndrome model. Eur J Med Chem. 2024 Feb 5;265:116098. (Q1)


Turbant F, Mosca K, Busi F, Arluison V, Wien F. Circular and Linear Dichroism for the Analysis of Small Noncoding RNA Properties. Methods Mol Biol. 2024;2741:399-416. (Q4)




Schvartz M, Saudrais F, Devineau S, Chédin S, Jamme F, Leroy J, Rakotozandriny K, Taché O, Brotons G, Pin S, Boulard Y, Renault JP. Role of the Protein Corona in the Colloidal Behavior of Microplastics. Langmuir. 2023 Mar 28;39(12):4291-4303. (Q1)


Giraudon-Colas G, Devineau S, Marichal L, Barruet E, Zitolo A, Renault JP, Pin S. How Nanoparticles Modify Adsorbed Proteins: Impact of Silica Nanoparticles on the Hemoglobin Active Site. Int J Mol Sci. 2023 Feb 11;24(4):3659. (Q1)


Schvartz M, Saudrais F, Devineau S, Aude JC, Chédin S, Henry C, Millán- Oropeza A, Perrault T, Pieri L, Pin S, Boulard Y, Brotons G, Renault JP. A proteome scale study reveals how plastic surfaces and agitation promote protein aggregation. Sci Rep. 2023 Jan 21;13(1):1227. (Q1)


Chivé C, Mc Cord C, Sanchez-Guzman D, Brookes O, Joseph P, Lai Kuen R, Phan G, Baeza Squiban A, Devineau S, Boland S. 3D model of the bronchial epithelial barrier to study repeated exposure to xenobiotics: Application to silver nanoparticles. Environ Toxicol Pharmacol. 2023 Oct;103:104281. (Q1)


Varela-Feijoo A, Djemia P, Narita T, Pignon F, Baeza-Squiban A, Sirri V, Ponton A. Multiscale investigation of viscoelastic properties of aqueous solutions of sodium alginate and evaluation of their biocompatibility. Soft Matter. 2023 Aug 9;19(31):5942-5955. (Q1)


Puisney-Dakhli C, Oikonomou EK, Tharaud M, Sivry Y, Berret JF, Baeza-Squiban A. Effects of brake wear nanoparticles on the protection and repair functions of the airway epithelium. Environ Pollut. 2023 Jun 15;327:121554. (Q1)


Deval G, Nedder M, Degrelle S, Rogozarski J, Vignaud ML, Chissey A, Colzin S, Laguillier Morizot C, Coumoul X, Boland S, Fournier T, Zerrad-Saadi A, Ferecatu I. Benzo(a)pyrene and Cerium Dioxide Nanoparticles in Co-Exposure Impair Human Trophoblast Cell Stress Signaling. Int J Mol Sci. 2023 Mar 12;24(6):5439. (Q1)


Richard A, Bruat C, Febvrel D, Squinazi F, Simos J, Zmirou-Navier D; members of the HCSP working group. Creation and testing of the Domiscore-a tool to characterize the impact of housing on health and well-being. BMC Public Health. 2023 May 4;23(1):815. (Q1)


** de Thonel A, Ahlskog JK, Daupin K, Dubreuil V, Berthelet J, Chaput C, Pires G, Leonetti C, Abane R, Barris LC, Leray I, Aalto AL, Naceri S, Cordonnier M, Benasolo C, Sanial M, Duchateau A, Vihervaara A, Puustinen MC, Miozzo F, Fergelot P, Lebigot É, Verloes A, Gressens P, Lacombe D, Gobbo J, Garrido C, Westerheide SD, David L, Petitjean M, Taboureau O, Rodrigues-Lima F, Passemard S, Sabéran-Djoneidi D, Nguyen L, Lancaster M, Sistonen L, Mezger V. Author Correction: CBP-HSF2 structural and functional interplay in Rubinstein-Taybi neurodevelopmental disorder. Nat Commun. 2023 Sep 28;14(1):6067.  Erratum for: Nat Commun. 2022 Nov 16;13(1):7002. (Q1)


Schator D, Mondino S, Berthelet J, Di Silvestre C, Ben Assaya M, Rusniok C, Rodrigues-Lima F, Wehenkel A, Buchrieser C, Rolando M. Legionella para-effectors target chromatin and promote bacterial replication. Nat Commun. 2023 Apr 14;14(1):2154. (Q1)


** Montalban E, Walle R, Castel J, Ansoult A, Hassouna R, Foppen E, Fang X, Hutelin Z, Mickus S, Perszyk E, Petitbon A, Berthelet J, Rodrigues-Lima F, Cebrian-Serrano A, Gangarossa G, Martin C, Trifilieff P, Bosch-Bouju C, Small DM, Luquet S. The Addiction Susceptibility TaqIA/Ankk1 Controls Reward and Metabolism Through D<sub>2</sub> Receptor-Expressing Neurons. Biol Psychiatry. 2023 Sep 1;94(5):424-436. (Q1)


Boy M, Bisio V, Zhao LP, Guidez F, Schell B, Lereclus E, Henry G, Villemonteix J, Rodrigues-Lima F, Gagne K, Retiere C, Larcher L, Kim R, Clappier E, Sebert M, Mekinian A, Fain O, Caignard A, Espeli M, Balabanian K, Toubert A, Fenaux P, Ades L, Dulphy N. Myelodysplastic Syndrome associated TET2 mutations affect NK cell function and genome methylation. Nat Commun. 2023 Feb 3;14(1):588. (Q1)




Nian Q, Li Y, Li J, Zhao L, Rodrigues Lima F, Zeng J, Liu R, Ye Z. U2AF1 in various neoplastic diseases and relevant targeted therapies for malignant cancers with complex mutations. Oncol Rep. 2024 Jan;51(1):5.


Marano F. Les méthodes alternatives à l’expérimentation animale, présent et futur [Alternative methods to animal testing, present and future]. Biol Aujourdhui. 2023;217(3-4):199-205.


Arnaud T, Rodrigues-Lima F, Viguier M, Deshayes F. Interplay between EGFR, E-cadherin, and PTP1B in epidermal homeostasis. Tissue Barriers. 2023 Jul 3;11(3):2104085.


Gallais Y, Alekhin A, Devineau S. Spectroscopie et imagerie Raman : des matériaux quantiques à la matière vivante. Photoniques, 2023, 121: 31-35.




Martin S, de Haan L, Estruch IM, EderKM, Marzi A, Schnekenburger J, Blosi M, Costa A Antonello G, Bergamaschi E, Riganti C, Beal D, Carrière M, Taché O, Hutchison G, Malone E, Young L, Campagnolo L, La Civita F, Pietroiusti A, Devineau S, Baeza A, Boland S, Zong C, Ichihara G, Fadeel B, Bouwmeester H. Pre-validation of a reporter gene assay for oxidative stress for the rapid screening of nanobiomaterials. Front. Toxicol. 2022 4: 974429. (Q1)

** Herrera Moro Chao D, Kirchner MK, Pham C, Foppen E, Denis RGP, Castel J, Morel C, Montalban E, Hassouna R, Bui LC, Renault J, Mouffle C, García-Cáceres C, Tschöp MH, Li D, Martin C, Stern JE, Luquet SH. Hypothalamic astrocyte control systemic glucose metabolism and energy balance. Cell Metab. 2022 Oct 4;34(10):1532-1547.e6. (Q1)

Larigot L, Bui LC, de Bouvier M, Pierre O, Pinon G, Fiocca J, Ozeir M, Tourette C, Ottolenghi C, Imbeaud S, Pontoizeau C, Blaise BJ, Chevallier A, Tomkiewicz C, Legrand B, Elena-Herrmann B, Néri C, Brinkmann V, Nioche P, Barouki R, Ventura N, Dairou J, Coumoul X. Identification of Modulators of the C.&amp;nbsp;elegans Aryl Hydrocarbon Receptor and Characterization of Transcriptomic and Metabolic AhR-1 Profiles. Antioxidants (Basel). 2022 May 23;11(5):1030. (Q1)

**Villares M, Lourenço N, Berthelet J, Lamotte S, Regad L, Medjkane S, Prina E, Rodrigues-Lima F, Späth GF, Weitzman JB. Trifloxystrobin blocks the growth of Theileria parasites and is a promising drug to treat Buparvaquone resistance. Commun Biol. 2022 5(1):1253. (Q1).

Gregoricchio S, Polit L, Esposito M, Berthelet J, Delestré L, Evanno E, Diop M, Gallais I, Aleth A, Poplineau M, Rosenbauer F, Rodrigues-Lima F, Duprez E, Boeva E, Guillouf C. HDAC1 and PRC2 mediate combinatorial control in SPI1/PU.1-dependent gene repression in murine erythroleukaemia. Nucleic Acids Res. 2022 Aug 12;50(14):7938-7958. (Q1)

Liu R, Sun Y, Berthelet J, Bui LC, Xu X, Viguier M, Dupret JM, Deshayes F, Rodrigues Lima F. Biochemical, enzymatic and computational characterization of recurrent somatic mutations of the human protein tyrosine phosphatase PTP1B in primary mediastinal B cell lymphoma. Int J Mol Sci. 2022 Jun 24;23(13):7027. (Q1)

**Liu R, Zhang W, Gou P, Berthelet J, Nian Q, Chevreux G, Legros V, Moroy G, Bui LC, Wang L, Dupret JM, Deshayes F, Rodrigues Lima F. Cisplatin causes covalent inhibition of protein- tyrosine phosphatase 1B (PTP1B) through reaction with its active site cysteine: molecular, cellular and in vivo mice studies. Biomed Pharmacother. 2022 Sep;153:113372. (Q1)

Ribeiro LW, Pietri M, Ardila-Osorio H, Baudry A, Boudet-Devaud F, Bizingre C, Arellano-Anaya ZE, Haeberlé AM, Gadot N, Boland S, Devineau S, Bailly Y, kellermann O, Bencsik A, Schneider B. Titanium dioxide and carbon black nanoparticles disrupt neuronal homeostasis via excessive activation of cellular prion protein signaling. Part Fibre Toxicol. 2022 Jul 15;19(1):48. (Q1)

**De Thonel A, Ahlskog JK, Daupin K, Dubreuil V, Berthelet J, Chaput C, Pires G, Leonetti C, Abane R, Cordón Barris L, Leray I, Aalto AL, Naceri S, Cordonnier M, Benasolo C, Sanial M, Duchateau A, Vihervaara A, Puustinen MA, Miozzo F, Fergelot P, Lebigot E, Verloes A, Gressens P, Lacombe D, Gobbo J, Garrido C, Westerheide SD, David L, Petitjean M, Taboureau O, Rodrigues Lima F, Passemard S, Sabéran-Djoneidi D, Nguyen L, Lancaster M, Sistonen L, Mezger V. CBP-HSF2 structural and functional interplay in Rubinstein-Taybi neurodevelopmental disorder. Nat Commun. 2022 Nov 16;13(1):7002 (Q1)

Charbit-Henrion F, Goguyer-Deschaumes R, Borensztajn K, Mirande M, Berthelet J, Rodrigues-Lima F, Khiat A, Frémond ML, Bader-Meunier B, Rodari MM, Seabra L, Rice GI, Legendre M, Drummond D, Berteloot L, Roux CJ, Boddaert N, Drabent P, Molina TJ, Lacaille F, Kossorotoff M, Cerf-Bensussan N, Parlato M, Hadchouel A. Systemic inflammatory syndrome in children with FARSA deficiency. Clin Genet. 2022 May;101(5-6):552-558. (Q1)

Sirri V, Berthelet J, Brookes O, Roussel P. Naphthoquinone-induced arylation inhibits Sirtuin 7 activity. J Cell Sci. 2022 Apr 15;135(8). (Q1)

Pareek V, Gupta R, Devineau S, Sivasankaran SK, Bhargava A, Khan MA, Srikumar S, Fanning S, Panwar J. Does Silver in Different Forms Affect Bacterial Susceptibility and Resistance? A Mechanistic Perspective. ACS Appl Bio Mater. 2022 Feb 21;5(2):801-817. (Q1)

Nian Q, Berthelet J, Parlato M, Mechaly AE, Liu R, Dupret JM, Cerf-Bensussan N, Haouz A, Rodrigues Lima F. Structural characterization of a pathogenic mutant of human protein tyrosine phosphatase PTPN2 (Cys216Gly) that causes very early onset autoimmune enteropathy. Protein Sci. 2022 Feb;31(2):538-544. (Q1)

Deshayes F, Fradet M, Kaminski S, Viguier M, Frippiat JP, Ghislin S. Link between the EZH2 noncanonical pathway and microtubule organization center polarization during early T lymphopoiesis Sci Rep. 2022 Mar 7;12(1):3655. (Q1)




**Avet C, Paul EN, Garrel G, Grange-Messent V, L’Hôte D, Denoyelle C, Corre R, Dupret JM, Lanone S, Boczkowski J, Simon V, Cohen-Tannoudji J. Carbon Black Nanoparticles Selectively Alter Follicle-Stimulating Hormone Expression in vitro and in vivo in Female Mice. Front Neurosci. 2021 Dec 6;15:780698. (Q1)

**Brookes O, Boland S, Lai Kuen R, Miremont D, Movassat J, Baeza-Squiban A. Co- culture of type I and type II pneumocytes as a model of alveolar epithelium. PLoS One. 2021 Sep 27;16(9):e0248798. (Q1)

Sanchez-Guzman D, Boland S, Brookes O, Mc Cord C, Lai Kuen R, Sirri V, Baeza Squiban A, Devineau S. Long-term evolution of the epithelial cell secretome in preclinical 3D models of the human bronchial epithelium. Sci Rep. 2021 Mar 23;11(1):6621. (Q1)

Zhang W, Lopez H, Boselli L, Bigini P, Perez-Potti A, Xie Z, Castagnola V, Cai Q, Silveira CP, de Araujo JM, Talamini L, Panini N, Ristagno G, Violatto MB, Devineau S, Monopoli MP, Salmona M, Giannone VA, Lara S, Dawson KA, Yan Y. A Nanoscale Shape-Discovery Framework Supporting Systematic Investigations of Shape-Dependent Biological Effects and Immunomodulation. ACS Nano. 2021 Dec 27. (Q1)

Anes J, Dever K, Eshwar A, Nguyen S, Cao Y, Sivasankaran SK, Sakalauskaitė S, Lehner A, Devineau S, Daugelavičius R, Stephan R, Fanning S, Srikumar S. Analysis of the Oxidative Stress Regulon Identifies soxSas a Genetic Target for Resistance Reversal in Multidrug- Resistant Klebsiella pneumoniae. mBio. 2021 Jun 29;12(3):e0086721. (Q1)

Pareek V, Devineau S, Sivasankaran SK, Bhargava A, Panwar J, Srikumar S, Fanning S. Silver Nanoparticles Induce a Triclosan-Like Antibacterial Action Mechanism in Multi-Drug Resistant Klebsiella pneumoniae. Front Microbiol. 2021 Feb 15;12:638640. (Q1)

Liang S, Zhou X, Cai D, Rodrigues-Lima F, Chi J, Wang L. Network Pharmacology and Experimental Validation Reveal the Effects of Chidamide Combined With Aspirin on Acute Myeloid Leukemia-Myelodysplastic Syndrome Cells Through PI3K/AKT Pathway. Front Cell Dev Biol. 2021 Sep 9;9:685954. (Q1)

Berthelet J, Michail C, Bui LC, Le Coadou L, Sirri V, Wang L, Dulphy N, Dupret JM, Chomienne C, Guidez F, Rodrigues-Lima F. The Benzene Hematotoxic and Reactive Metabolite 1,4- Benzoquinone Impairs the Activity of the Histone Methyltransferase SET Domain Containing 2 (SETD2) and Causes Aberrant Histone H3 Lysine 36 Trimethylation (H3K36me3). Mol Pharmacol. 2021 Sep;100(3):283-294. (Q1)

Liang S, Zhou X, Cai D, Rodrigues-Lima F, Wang L. Chidamide Inhibits Cell Proliferation via the PI3K/AKT Pathway in K562 Cells Based on Network Pharmacology and Experimental Validation. Curr Pharm    Des. 2021;27(26):2990-2998. (Q2)

Cheeseman K, Jannot G, Lourenço N, Villares M, Berthelet J, Calegari-Silva T, Hamroune J, Letourneur F, Rodrigues-Lima F, Weitzman JB. Dynamic methylation of histone H3K18 in differentiating Theileria parasites. Nat Commun. 2021 May 28;12(1):3221. (Q1)

Zhang W, Berthelet J, Michail C, Bui LC, Gou P, Liu R, Duval R, Renault J, Dupret JM, Guidez F, Chomienne C, Rodrigues Lima F. Human CREBBP acetyltransferase is impaired by etoposide quinone, an oxidative and leukemogenic metabolite of the anticancer drug etoposide through modification of redox-sensitive zinc-finger cysteine residues. Free Radic Biol Med. 2021 Jan;162:27-37. (Q1)

**Lizarralde-Iragorri MA, Lefevre SD, Cochet S, El Hoss S, Brousse V, Filipe A, Dussiot M, Azouzi S, Le Van Kim C, Rodrigues-Lima F, Français O, Le Pioufle B, Klei T, van Bruggen R, El Nemer W. Oxidative stress activates red cell adhesion to laminin in sickle cell disease. Haematologica. 2021 Sep 1;106(9):2478-2488. (Q1)




**Crobeddu B, Baudrimont I, Deweirdt J, Sciare J, Badel A, Camproux AC, Bui LC, Baeza- Squiban A. Lung Antioxidant Depletion: A Predictive Indicator of Cellular Stress Induced by Ambient Fine Particles. Environ Sci Technol. 2020 Feb 18;54(4):2360-2369. (Q1)

Radiom M, He Y, Peng-Wang J, Baeza-Squiban A, Berret JF, Chen Y. Alveolar mimics with periodic strain and its effect on the cell layer formation. Biotechnol Bioeng. 2020 Sep;117(9):2827-2841. (Q1)

Sanchez-Guzman D, Giraudon-Colas G, Marichal L, Boulard Y, Wien F, Degrouard J, Baeza- Squiban A, Pin S, Renault JP, Devineau S. In Situ Analysis of Weakly Bound Proteins Reveals Molecular Basis of Soft Corona Formation. ACS Nano. 2020 Jul 28;14(7):9073-9088. (Q1)

Nedder M, Boland S, Devineau S, Zerrad-Saadi A, Rogozarski J, Lai-Kuen R, Baya I, Guibourdenche J, Vibert F, Chissey A, Gil S, Coumoul X, Fournier T, Ferecatu I. Uptake of Cerium Dioxide Nanoparticles and Impact on Viability, Differentiation and Functions of Primary Trophoblast Cells from Human Placenta. Nanomaterials (Basel). 2020 Jul 3;10(7):1309. (Q1)

Tada-Oikawa S, Eguchi M, Yasuda M, Izuoka K, Ikegami A, Vranic S, Boland S, Tran L, Ichihara G, Ichihara S. Functionalized Surface-Charged SiO2 Nanoparticles Induce Pro-Inflammatory Responses, but Are Not Lethal to Caco-2 Cells. Chem Res Toxicol. 2020 May 18;33(5):1226- 1236. (Q2)

Parlato M, Nian Q, Charbit-Henrion F, Ruemmele FM, Rodrigues-Lima F, Cerf-Bensussan N; Immunobiota Study Group. Loss-of-Function Mutation in PTPN2 Causes Aberrant Activation of JAK Signaling Via STAT and Very Early Onset Intestinal Inflammation. Gastroenterology. 2020 Nov;159(5):1968-1971.e4. (Q1)

Xu X, Zhang W, Berthelet J, Liu R, Michail C, Chaffotte AF, Dupret JM, Rodrigues-Lima F. From transglutaminases (TGs) to arylamine N-acetyltransferases (NATs): Insight into the role of a spatially conserved aromatic amino acid position in the active site of these two families of enzymes. Biochem Biophys Res Commun. 2020 Apr 30;525(2):308-312. (Q1)

Radiom M, Sarkis M, Brookes O, Oikonomou EK, Baeza-Squiban A, Berret JF. Pulmonary surfactant inhibition of nanoparticle uptake by alveolar epithelial cells. Sci Rep. 2020 Nov 10;10(1):19436. (Q1)

Adon J, Liousse C, Doumbia T, Baeza-Squiban A, Cachier H, Leon F, Yoboue V, Akpo Ab, Galy- Lacaux C, Zoutien C, Xu H, Gardrat E, Keita S. (2020) Physico-chemical characterization of urban aerosols from specific combustion sources in West Africa at Abidjan in Côte d’Ivoire and Cotonou in Benin in the frame of DACCIWA program. Atmos. Chem. Phys; doi.org/10.5194/acp-2019-406. (Q1)




Vranic S, Shimada Y, Ichihara S, Kimata M, Wu W, Tanaka T, Boland S, Tran L, Ichihara G. Toxicological Evaluation of SiO₂ Nanoparticles by Zebrafish Embryo Toxicity Test. Int J Mol Sci. 2019 Feb 18;20(4). (Q1)

Sirri V, Grob A, Berthelet J, Jourdan N, Roussel P. Sirtuin 7 promotes 45S pre-rRNA cleavage at site 2 and determines the processing pathway. J Cell Sci. 2019 Sep 2;132(17). (Q1)

**Denis RGP, Busi F, Castel J, Morel C, Zhang W, Bui LC, Sugamori KS, Prokopec SD, Boutros PC, Grant DM, Rodrigues-Lima F, Luquet S, Dupret JM. A readout of metabolic efficiency in arylamine N-acetyltransferase-deficient mice reveals minor energy metabolism changes. FEBS Lett. 2019 Apr;593(8):831-841. (Q1)

Duval R, Bui LC, Mathieu C, Nian Q, Berthelet J, Xu X, Haddad I, Vinh J, Dupret JM, Busi F, Guidez F, Chomienne C, Rodrigues-Lima F. Benzoquinone, a leukemogenic metabolite of benzene, catalytically inhibits the protein tyrosine phosphatase PTPN2 and alters STAT1 signaling. J Biol Chem. 2019 Aug 16;294(33):12483-12494. (Q1)

Nian Q, Berthelet J, Zhang W, Bui LC, Liu R, Xu X, Duval R, Ganesan S, Leger T, Chomienne C, Busi F, Guidez F, Dupret JM, Rodrigues Lima F. T-Cell Protein Tyrosine Phosphatase Is Irreversibly Inhibited by Etoposide-Quinone, a Reactive Metabolite of the Chemotherapy Drug Etoposide. Mol Pharmacol. 2019 Aug;96(2):297-306. (Q1)




Wakx A, Nedder M, Tomkiewicz-Raulet C, Dalmasso J, Chissey A, Boland S, Vibert F, Degrelle SA, Fournier T, Coumoul X, Gil S, Ferecatu I. Expression, Localization, and Activity of the Aryl Hydrocarbon Receptor in the Human Placenta. Int J Mol Sci. 2018 Nov 27;19(12). (Q1)

**London J, Ndiaye FK, Bui LC, Souchet B, Daubigney F, Magnan C, Luquet S, Dairou J, Janel N, Rouch C. Alterations in the Serotonin and Dopamine Pathways by Cystathionine Beta Synthase Overexpression in Murine Brain. Mol Neurobiol. 2019 Jun;56(6):3958-3971. (Q1)

Malabirade A, Partouche D, El Hamoui O, Turbant F, Geinguenaud F, Recouvreux P, Bizien T, Busi F, Wien F, Arluison V. Revised role for Hfq bacterial regulator on DNA topology. Sci Rep. 2018 Nov 14;8(1):16792. (Q1)

Devineau S, Kiger L, Galacteros F, Baudin-Creuza V, Marden M, Renault JP, Pin S. Manipulating hemoglobin oxygenation using silica nanoparticles: a novel prospect for artificial oxygen carriers. Blood Adv. 2018 Jan 23;2(2):90-94. (Q1)

Sevin M, Kubovcakova L, Pernet N, Causse S, Vitte F, Villeval JL, Lacout C, Cordonnier M, Rodrigues-Lima F, Chanteloup G, Mosca M, Chrétien ML, Bastie JN, Audia S, Sagot P, Ramla S, Martin L, Gleave M, Mezger V, Skoda R, Plo I, Garrido C, Girodon F, de Thonel A. HSP27 is a partner of JAK2-STAT5 and a potential therapeutic target in myelofibrosis. Nat Commun. 2018 Apr 12;9(1):1431. (Q1)

Neumann F, Gourdain S, Albac C, Dekker AD, Bui LC, Dairou J, Schmitz-Afonso I, Hue N, Rodrigues-Lima F, Delabar JM, Potier MC, Le Caër JP, Touboul D, Delatour B, Cariou K, Dodd RH. DYRK1A inhibition and cognitive rescue in a Down syndrome mouse model are induced by new fluoro-DANDY derivatives. Sci Rep. 2018 Feb 12;8(1):2859. (Q1)

Puisney C, Oikonomou E, Nowak S, Chevillot A, Casale S, Baeza-Squiban A, Berret JF. Brake wear (nano)particle characterization and toxicity on airway epithelial cells in vitro. Environ Sci: Nano. 2018 ; 5 :1036-1044. (Q1)

**London J, Rouch C, Bui LC, Assayag E, Souchet B, Daubigney F, Medjaoui H, Luquet S, Magnan C, Delabar JM, Dairou J, Janel N. Overexpression of the DYRK1A Gene (Dual-Specificity Tyrosine Phosphorylation-Regulated Kinase 1A) Induces Alterations of the Serotoninergic and Dopaminergic Processing in Murine Brain Tissues. Mol Neurobiol. 2018 May;55(5):3822- 3831. (Q1)




Mousseau F, Puisney C, Mornet S, Borgne RL, Vacher A, Airiau M, Baeza-Squiban A, Berret JF. Supported pulmonary surfactant bilayers on silica nanoparticles: formulation, stability and impact on lung epithelial cells. Nanoscale. 2017 Oct 12;9(39):14967-14978. (Q1)

Deweirdt J, Quignard JF, Crobeddu B, Baeza-Squiban A, Sciare J, Courtois A, Lacomme S, Gontier E, Muller B, Savineau JP, Marthan R, Guibert C, Baudrimont I. Involvement of oxidative stress and calcium signaling in airborne particulate matter – induced damages in human pulmonary artery endothelial cells. Toxicol In Vitro. 2017 Dec;45(Pt 3):340-350. (Q2)

Crobeddu B, Aragao-Santiago L, Bui LC, Boland S, Baeza Squiban A. Oxidative potential of particulate matter 2.5 as predictive indicator of cellular stress. Environ Pollut. 2017 Nov;230:125-133. (Q1)

Vranic S, Gosens I, Jacobsen NR, Jensen KA, Bokkers B, Kermanizadeh A, Stone V, Baeza- Squiban A, Cassee FR, Tran L, Boland S. Impact of serum as a dispersion agent for in vitro and in vivo toxicological assessments of TiO(2) nanoparticles. Arch Toxicol. 2017 Jan;91(1):353-63. (Q1)

García-Ramírez I, Tadros S, González-Herrero I, Martin-Lorenzo A, Rodríguez-Hernández G, Moore D, Ruiz-Roca L, Blanco O, Alonso-López D, Rivas JL, Hartert K, Duval R, Klinkebiel D, Bast M, Vose J, Lunning M, Fu K, Greiner T, Rodrigues-Lima F, Jiménez R, Criado FJG, Cenador MBG, Brindle P, Vicente-Dueñas C, Alizadeh A, Sánchez-García I, Green MR. Crebbp loss cooperates with Bcl2 overexpression to promote lymphoma in mice. Blood. 2017 May 11;129(19):2645-2656. (Q1)

**Simon V, Avet C, Grange-Messent V, Wargnier R, Denoyelle C, Pierre A, Dairou J, Dupret JM, Cohen-Tannoudji J. Carbon Black Nanoparticles Inhibit Aromatase Expression and Estradiol Secretion in Human Granulosa Cells Through the ERK1/2 Pathway. Endocrinology. 2017 Oct 1;158(10):3200-3211. (Q1)

Xu X, Mathieu C, Berthelet J, Duval R, Bui LC, Busi F, Dupret JM, Rodrigues-Lima F. Human Arylamine N-Acetyltransferase 1 Is Inhibited by the Dithiocarbamate Pesticide Thiram. Mol Pharmacol. 2017 Sep;92(3):358-365. (Q1)

Kubiak X, Duval R, Pluvinage B, Chaffotte AF, Dupret JM, Rodrigues-Lima F. Xenobiotic- metabolizing enzymes in Bacillus anthracis: molecular and functional analysis of a truncated arylamine N-acetyltransferase isozyme. Br J Pharmacol. 2017 Jul;174(14):2174-2182.(Q1)

Mathieu C, Bui LC, Petit E, Haddad I, Agbulut O, Vinh J, Dupret JM, Rodrigues-Lima F. Molecular Mechanisms of Allosteric Inhibition of Brain Glycogen Phosphorylase by Neurotoxic Dithiocarbamate Chemicals. J Biol Chem. 2017 Feb 3;292(5):1603-1612. (Q1)

Mathieu C, Dupret JM, Rodrigues Lima F. The structure of brain glycogen phosphorylase- from allosteric regulation mechanisms to clinical perspectives. FEBS J. 2017 Feb;284(4):546- 554. (Q1)

Delaval M, Wohlleben W, Landsiedel R, Baeza-Squiban A, Boland S. Assessment of the oxidative potential of nanoparticles by the cytochrome c assay: assay improvement and development of a high-throughput method to predict the toxicity of nanoparticles. Arch Toxicol. 2017 Jan;91(1):163-177. (Q1)




Liu R, Mathieu C, Berthelet J, Zhang W, Dupret JM, Rodrigues Lima F. Human protein tyrosine phosphatase 1B (PTP1B), from structure to clinical inhibitor perspectives. Int J Mol Sci. 2022 Jun 24;23(13):7027. (Q1)

Busi F, Turbant F, Waeytens J, El Hamoui, Wien F, Arluison V. Evaluation of Amyloid Inhibitor Efficiency to Block Bacterial Survival. Methods Mol Biol. 2022 2538:145-163. (Q4)

Nian Q, Li J, Han Z, Liang Q, Liu M, Yang C, Rodrigues-Lima F, Jiang T, Zhao L, Zeng J, Liu C, Shi J. SPARC in hematologic malignancies and novel technique for hematological disease with its abnormal expression. Biomed Pharmacother. 2022 153:113519. (Q1)


Deval G, Boland S, Fournier T, Ferecatu I. On Placental Toxicology Studies and Cerium Dioxide Nanoparticles. Int J Mol Sci. 2021 Nov 12;22(22):12266. (Q1)

Hu Y, Anes J, Devineau S, Fanning S. Klebsiella pneumoniae: Prevalence, Reservoirs, Antimicrobial Resistance, Pathogenicity, and Infection: A Hitherto Unrecognized Zoonotic Bacterium. Foodborne Pathog Dis. 2021 Feb;18(2):63-84. (Q1)

Zhang W, Gou P, Dupret JM, Chomienne C, Rodrigues-Lima F. Etoposide, an anticancer drug involved in therapy-related secondary leuk€mia: Enzymes at play. Transl Oncol. 2021 Oct;14(10):101169. (Q2)

Barouki R, Kogevinas M, Audouze K, Belesova K, Bergman A, Birnbaum L, Boekhold S, Denys S, Desseille C, Drakvik E, Frumkin H, Garric J, Destoumieux-Garzon D, Haines A, Huss A, Jensen G, Karakitsios S, Klanova J, Kosk€la IM, Laden F, Marano F, Franziska Matthies-Wiesler E, Morris G, Nowacki J, Paloniemi R, Pearce N, Peters A, Rekola A, Sarigiannis D, Šebková K, Slama R, Staatsen B, Tonne C, Vermeulen R, Vineis P; HERA-COVID-19 working group. The COVID-19 pandemic and global environmental change: Emerging research needs. Environ Int. 2021 Jan;146:106272. (Q1)

Busi F. Fluorescent Oligonucleotide Probes for the Quantification of RNA by Real-Time qPCR. Methods Mol Biol. 2020;2113:263-280. (Q4)

Mathieu C, Dupret JM, Rodrigues-Lima F. The Structure and the Regulation of Glycogen Phosphorylases in Brain. Adv Neurobiol. 2019;23:125-145. (Q2)

Puisney C, Baeza-Squiban A, Boland S. Mechanisms of Uptake and Translocation of Nanomaterials in the Lung. Adv Exp Med Biol. 2018;1048:21-36. (Q3)

Busi F, Arluison V, Régnier P. Absolute Regulatory Small Noncoding RNA Concentration and Decay Rates Measurements in Escherichia coli. Methods Mol Biol. 2018;1737:231-248. (Q4)

Hellack B, Nickel C, Albrecht C, Kuhlbusch TAJ, Boland S, Baeza-Squiban A, Wohlleben W, Schins RPF. Analytical methods to assess the oxidative potential of nanoparticles: a review. Environ Sci: Nano. 2017 ; 4:1920-1934. (Q1)

Stone V, Miller MR, Clift MJD, Elder A, Mills NL, Møller P, Schins RPF, Vogel U, Kreyling WG, Alstrup Jensen K, Kuhlbusch TAJ, Schwarze PE, Hoet P, Pietroiusti A, De Vizcaya-Ruiz A, Baeza-Squiban A, Teixeira JP, Tran CL, Cassee FR. Nanomaterials Versus Ambient Ultrafine Particles: An Opportunity to Exchange Toxicology Knowledge. Environ Health Perspect. 2017 Oct 10;125(10):106002. (Q1)