Degenerative Processes, Stress and Aging
Selected publications
1/ Postic G, Janel N, Moroy G. Representations of protein structure for exploring the conformational space: A speed-accuracy trade-off. Comput Struct Biotechnol J. 2021 Apr 28;19:2618-2625. doi: 10.1016/j.csbj.2021.04.049. PMID: 34025948; PMCID: PMC8120936.
2/ Teseo S, Houot B, Yang K, Monnier V, Liu G, Tricoire H. G. sinense and P. notoginseng Extracts Improve Healthspan of Aging Flies and Provide Protection in A Huntington Disease Model. Aging Dis. 2021 Apr 1;12(2):425-440. doi: 10.14336/AD.2020.0714-1. PMID: 33815875; PMCID: PMC7990376.
3/ Russi M, Martin E, D’Autréaux B, Tixier L, Tricoire H, Monnier V. A Drosophila model of Friedreich ataxia with CRISPR/Cas9 insertion of GAA repeats in the frataxin gene reveals in vivo protection by N-acetyl cysteine. Hum Mol Genet. 2020 Oct 10;29(17):2831-2844. doi: 10.1093/hmg/ddaa170. PMID: 32744307.
4/ Souchet B, Audrain M, Billard JM, Dairou J, Fol R, Orefice NS, Tada S, Gu Y, Dufayet-Chaffaud G, Limanton E, Carreaux F, Bazureau JP, Alves S, Meijer L, Janel N, Braudeau J, Cartier N. Inhibition of DYRK1A proteolysis modifies its kinase specificity and rescues Alzheimer phenotype in APP/PS1 mice. Acta Neuropathologica Communications, 2019, 7, 46.
5/ Sowa AS, Martin E, Martins IM, Schmidt J, Depping R, Weber JJ, Rother F, Hartmann E, Bader M, Riess O, Tricoire H, Schmidt T. Karyopherin α-3 is a key protein in the pathogenesis of spinocerebellar ataxia type 3 controlling the nuclear localization of ataxin-3. Proc Natl Acad Sci U S A. 2018 Mar 13;115(11):E2624-E2633.
Publications in peer-reviewed journals (since 2017)
** Publications shared with other teams of BFA.
Quartiles as from Scimago Journal & Country Rank are reported at the end of each publication.
Original articles
2024
** Delabar JM, Gomes MAGB, Fructuoso M, Sarrazin N, George N, Fleary-Roberts N, Sun H, Bui LC, Rodrigues-Lima F, Janel N, Dairou J, Maria EJ, Dodd RH, Cariou K, Potier MC. EGCG-like non-competitive inhibitor of DYRK1A rescues cognitive defect in a down syndrome model. Eur J Med Chem. 2024 Feb 5;265:116098. (Q1)
2023
**Dard R, Tutunaru A, Bouassida M, Balde Camara A, Parizot E, Kassis N, Fortemps J, Cierniewski C, Racine C, Clemente ND, Vialard F, Janel N. Spermatogonial depletion and a spermatogenesis defect in the Dp(16)1Yey mouse model of Down syndrome. Reproduction. 2023 Dec 1:REP-23-0233. (Q1)
Fructuoso M, Fernández-Blanco Á, Gallego-Román A, Sierra C, de Lagrán MM, Lorenzon N, De Toma I, Langohr K, Martín-García E, Maldonado R, Dairou J, Janel N, Dierssen M. Exploring the link between hedonic overeating and prefrontal cortex dysfunction in the Ts65Dn trisomic mouse model. Cell Mol Life Sci. 2023 Nov 21;80(12):370. (Q1)
**Postic G, Solarz J, Loubière C, Kandiah J, Sawmynaden J, Adam F, Vilaire M, Léger T, Camadro JM, Victorino DB, Potier MC, Bun E, Moroy G, Kauskot A, Christophe O, Janel N. Over-expression of Dyrk1A affects bleeding by modulating plasma fibronectin and fibrinogen level in mice. J Cell Mol Med. 2023 Aug;27(15):2228-2238. (Q2)
2022
Cieuta-Walti C, Cuenca Royo A, Langohr, K, Rakic, C, López Vílchez, A, Lirio, J, González-Lamuño Leguina, D, Bermejo González, T, García García, J, Rimblas Roure, M, Aldea Perona, A, Gomis, M, Videla Cés, S, Lacaille F, Ravel A, Mircher C, Walti, H, Janel N, Dairou J, Lévy M, Durand S, Dierssen M, Sacco S, De la Torre R. Safety and Preliminary Efficacy on Cognitive Performance and Adaptive Functionality of Epigallocatechin Gallate (EGCG) in Children with Down Syndrome. A Randomized Phase Ib Clinical Trial (PERSEUS study). Genetics in Medicine, 2022, 24, 2004-2013. (Q1)
Moreau M, Carmona-Iragui M, Altuna M, Dalzon L, Barroeta I, Vilaire M, Durand S, Fortea J, Rebillat AS, Janel N. DYRK1A and activity-dependent neuroprotective protein comparative diagnosis interest in cerebrospinal fluid and plasma in the context of Alzheimer-related cognitive impairment in Down syndrome patients. Biomedicines, 2022, 10, 1380. (Q1)
Souchet B, Audrain M, Gu Y, Lindberg MF, Orefice NS, Rey E, Cartier N, Janel N, Meijer L, Braudeau J. Cerebral Phospho-Tau Acts Synergistically with Soluble Aβ42 Leading to Mild Cognitive Impairment in AAV-AD Rats.J Prev Alzheimers Dis. 2022;9(3):480-490. (Q1)
Ader F, Russi M, Tixier-Cardoso L, Jullian E, Martin E, Richard P, Villard E, Monnier V. Drosophila CRISPR/Cas9 mutants as tools to analyse cardiac filamin function and pathogenicity of human FLNC variants. Biol Open. 2022 Sep 15;11(9):bio059376. (Q1)
**Cruciani-Guglielmacci C, Meneyrol K, Denom J, Kassis N, Rachdi L, Makaci F, Migrenne-Li S, Daubigney F, Georgiadou E, Denis RG, Rodriguez Sanchez-Archidona A, Paul JL, Thorens B, Rutter GA, Magnan C, Le Stunff H, Janel N. Homocysteine Metabolism Pathway Is Involved in the Control of Glucose Homeostasis: A Cystathionine Beta Synthase Deficiency Study in Mouse.Cells. 2022 May 25;11(11):1737. (Q1)
**Ghoula M, Janel N, Camproux AC, Moroy G. Exploring the structural rearrangements of the human Insulin Degrading Enzyme through Molecular Dynamics simulations. Int. J. Mol. Sci., 2022, 23, 1746. (Q1)
2021
llouz T, Biragyn A, Frenkel-Morgenstern M, Weissberg O, Gorohovski A, Merzon E, Green I, Iulita F, Flores-Aguilar L, Dierssen M, De Toma I, Lifshitz H, Antonarakis SE, Yu E, Herault Y, Potier MC, Botté A, Roper R, Sredni B, Sarid R, London J, Mobley W, Strydom A, Okun E. Specific Susceptibility to COVID-19 in Adults with Down Syndrome. Neuromolecular Med. 2021 Dec;23(4):561-571. (Q2)
**Dard R, Moreau M, Parizot E, Ghieh F, Brehier L, Kassis N, Serazin V, Lamaziere A, Racine C, di Clemente N, Vialard F, Janel N. DYRK1A Overexpression in Mice Downregulates the Gonadotropic Axis and Disturbs Early Stages of Spermatogenesis. Genes (Basel). 2021 Nov 16;12(11):1800. (Q2)
**Postic G, Janel N, Moroy G. Representations of protein structure for exploring the conformational space: A speed-accuracy trade-off. Comput Struct Biotechnol J. 2021 Apr 28;19:2618-2625. (Q1)
Martin E, Heidari R, Monnier V, Tricoire H. Genetic Screen in Adult Drosophila Reveals That dCBP Depletion in Glial Cells Mitigates Huntington Disease Pathology through a Foxo-Dependent Pathway. Int J Mol Sci. 2021 Apr 9;22(8):3884. (Q1)
Teseo S, Houot B, Yang K, Monnier V, Liu G, Tricoire H. G. sinense and P. notoginseng Extracts Improve Healthspan of Aging Flies and Provide Protection in A Huntington Disease Model. Aging Dis. 2021 Apr 1;12(2):425-440. (Q1)
2020
Russi M, Martin E, D’Autréaux B, Tixier L, Tricoire H, Monnier V. A Drosophila model of Friedreich ataxia with CRISPR/Cas9 insertion of GAA repeats in the frataxin gene reveals in vivo protection by N-acetyl cysteine. Hum Mol Genet. 2020 Oct 10;29(17):2831-2844. (Q1)
**Postic G, Janel N, Tufféry P, Moroy G. An information gain-based approach for evaluating protein structure models. Comput Struct Biotechnol J. 2020, 18, 2228-2236. (Q1)
**Fructuoso M, Gu YC, Kassis N, de Lagran MM, Dierssen M, Janel N. Ethanol- Induced Changes in Brain of Transgenic Mice Overexpressing DYRK1A. Mol Neurobiol. 2020 Jul;57(7):3195-3205. doi: 10.1007/s12035-020-01967-6. (Q1)
**Gu Y, Moroy G, Paul JL, Rebillat AS, Dierssen M, de la Torre R, Cieuta-Walti C, Dairou J, Janel N. Molecular Rescue of Dyrk1A Overexpression Alterations in Mice with Fontup Dietary Supplement: Role of Green Tea Catechins. Int J Mol Sci. 2020 Feb 19;21(4):1404. (Q1)
2019
**Le Stunff H, Véret J, Kassis N, Denom J, Meneyrol K, Paul JL, Cruciani-Guglielmacci C, Magnan C, Janel N. Deciphering the Link Between Hyperhomocysteinemia and Ceramide Metabolism in Alzheimer-Type Neurodegeneration. Front Neurol. 2019 Jul 31 ;10 :807. (Q1)
**London J, Ndiaye FK, Bui LC, Souchet B, Daubigney F, Magnan C, Luquet S, Dairou J, Janel N, Rouch C. Alterations in the Serotonin and Dopamine Pathways by Cystathionine Beta Synthase Overexpression in Murine Brain. Mol Neurobiol. 2019 Jun ;56(6):3958-3971. (Q1)
**Movassat J, Delangre E, Liu J, Gu Y, Janel N. Hypothesis and Theory: Circulating Alzheimer’s-Related Biomarkers in Type 2 Diabetes. Insight From the Goto-Kakizaki Rat. Front Neurol. 2019 Jun 26 ;10 :649. (Q2)
Souchet B, Audrain M, Billard JM, Dairou J, Fol R, Orefice NS, Tada S, Gu Y, Dufayet-Chaffaud G, Limanton E, Carreaux F, Bazureau JP, Alves S, Meijer L, Janel N, Braudeau J, Cartier N. Inhibition of DYRK1A proteolysis modifies its kinase specificity and rescues Alzheimer phenotype in APP/PS1 mice. Acta Neuropathol Commun. 2019 Mar 18 ;7(1) :46. (Q1)
Souchet B, Duchon A, Gu Y, Dairou J, Chevalier C, Daubigney F, Nalesso V, Créau N, Yu Y, Janel N, Herault Y, Delabar JM. Prenatal treatment with EGCG enriched green tea extract rescues GAD67 related developmental and cognitive defects in Down syndrome mouse models. Sci Rep. 2019 Mar 8 ;9(1):3914. (Q1)
**Latour A, Gu Y, Kassis N, Daubigney F, Colin C, Gausserès B, Middendorp S, Paul JL, Hindié V, Rain JC, Delabar JM, Yu E, Arbones M, Mallat M, Janel N. LPS-Induced Inflammation Abolishes the Effect of DYRK1A on IkB Stability in the Brain of Mice. Mol Neurobiol. 2019 Feb ;56(2) :963-975. (Q1)
2018
Artiushin G, Zhang SL, Tricoire H, Sehgal A. Endocytosis at the Drosophila blood-brain barrier as a function for sleep. Elife. 2018 Nov 26 ;7. pii: e43326. (Q1)
**Baloula V, Fructuoso M, Kassis N, Gueddouri D, Paul JL, Janel N. Homocysteine-lowering gene therapy rescues signaling pathways in brain of mice with intermediate hyperhomocysteinemia. Redox Biol. 2018 Oct ;19:200-209. (Q1)
Palandri A, Martin E, Russi M, Rera M, Tricoire H, Monnier V. Identification of cardioprotective drugs by medium-scale in vivo pharmacological screening on a Drosophila cardiac model of Friedreich’s ataxia. Dis Model Mech. 2018 Jul 20;11(7). (Q1)
**London J, Rouch C, Bui LC, Assayag E, Souchet B, Daubigney F, Medjaoui H, Luquet S, Magnan C, Delabar JM, Dairou J, Janel N. Overexpression of the DYRK1A Gene (Dual-Specificity Tyrosine Phosphorylation-Regulated Kinase 1A) Induces Alterations of the Serotoninergic and Dopaminergic Processing in Murine Brain Tissues. Mol Neurobiol. 2018 May ;55(5):3822-3831. (Q1)
**Fructuoso M, Rachdi L, Philippe E, Denis RG, Magnan C, Le Stunff H, Janel N, Dierssen M. Increased levels of inflammatory plasma markers and obesity risk in a mouse model of Down syndrome. Free Radic Biol Med. 2018 Jan; 114:122-130. Corrigendum in Free Radic Biol Med. 2018 Apr; 118:150. (Q1)
Sowa AS, Martin E, Martins IM, Schmidt J, Depping R, Weber JJ, Rother F, Hartmann E, Bader M, Riess O, Tricoire H, Schmidt T. Karyopherin α-3 is a key protein in the pathogenesis of spinocerebellar ataxia type 3 controlling the nuclear localization of ataxin-3. Proc Natl Acad Sci U S A. 2018 Mar 13;115(11):E2624-E2633. (Q1)
2017
Ragheb R, Chuyen A, Torres M, Defaye A, Seyres D, Kremmer L, Fernandez-Nunez N, Tricoire H, Rihet P, Nguyen C, Röder L, Perrin L. Interplay between trauma and Pseudomonas entomophila infection in flies: a central role of the JNK pathway and of CrebA. Sci Rep. 2017 Nov 24 ;7(1) :16222. (Q1)
**Janel N, Alexopoulos P, Badel A, Lamari F, Camproux AC, Lagarde J, Simon S, Feraudet-Tarisse C, Lamourette P, Arbones M, Paul JL, Dubois B, Potier MC, Sarazin M, Delabar JM. Combined assessment of DYRK1A, BDNF and homocysteine levels as diagnostic marker for Alzheimer’s disease. Transl Psychiatry. 2017 Jun 20 ;7(6) : e1154. (Q1)
Haddadi-Guemghar H, Tlili A, Dairou J, Paul JL, Madani K, Janel N. Effect of lyophilized prune extract on hyperhomocysteinemia in mice. Food Chem Toxicol. 2017 May ;103 :183-187. (Q1)
Reviews
**Hamzé R, Delangre E, Tolu S, Moreau M, Janel N, Bailbé D, Movassat J. Type 2 Diabetes Mellitus and Alzheimer’s Disease: Shared Molecular Mechanisms and Potential Common Therapeutic Targets. Int. J. Mol. Sci., 2022, Int J Mol Sci, 23, 15287. (Q1)
**Noll C, Kandiah J, Moroy G, Gu Y, Dairou J, Janel N. Catechins as a Potential Dietary Supplementation in Prevention of Comorbidities Linked with Down Syndrome. Nutrients. 2022 May 12;14(10):2039. doi: 10.3390/nu14102039. (Q1)
Hamzé R, Delangre E, Tolu S, Moreau M, Janel N, Bailbé D, Movassat J. Type 2 Diabetes Mellitus and Alzheimer’s Disease: Shared Molecular Mechanisms and Potential Common Therapeutic Targets.Int J Mol Sci. 2022 Dec 4;23(23):15287. doi: 10.3390/ijms232315287. (Q1)
**Moreau M, Benhaddou S, Dard R, Tolu S, Hamzé R, Vialard F, Movassat J, Janel N. Metabolic Diseases and Down Syndrome: How Are They Linked Together? Biomedicines. 2021 Feb 22;9(2):221. doi: 10.3390/biomedicines9020221. PMID: 33671490; PMCID: PMC7926648. (Q1)
Monnier V, Llorens JV, Navarro JA. Impact of Drosophila Models in the Study and Treatment of Friedreich’s Ataxia. Int J Mol Sci. 2018 Jul 7;19(7). pii: E1989. (Q1)
Parizot E, Dard R, Janel N, Vialard F. Down syndrome and infertility: what support should we provide? J Assist Reprod Genet. 2019 Jun ;36(6) :1063-1067. (Q1)
