Biology and Pathology of the Endocrine Pancreas

Selected publications

1/ Gausserès B, Liu J, Foppen E, Tourrel-Cuzin C, Rodriguez Sanchez-Archidona A, Delangre E, Cruciani-Guglielmacci C, Pons S, Maskos U, Thorens B, Magnan C, Movassat J, Maouche K. The Constitutive Lack of α7 Nicotinic Receptor Leads to Metabolic Disorders in Mouse. Biomolecules. 2020 Jul 16;10(7):1057. doi: 10.3390/biom10071057. PMID: 32708537; PMCID: PMC7408520.

2/ Pitasi CL, Liu J, Gausserès B, Pommier G, Delangre E, Armanet M, Cattan P, Mégarbane B, Hanak AS, Maouche K, Bailbé D, Portha B, Movassat J. Implication of glycogen synthase kinase 3 in diabetes-associated islet inflammation. J Endocrinol. 2020 Jan 1;244(1):133-148. doi: 10.1530/JOE-19-0239. PMID: 31600727.

3/ Quinault A, Gausseres B, Bailbe D, Chebbah N, Portha B, Movassat J, Tourrel-Cuzin C. Disrupted dynamics of F-actin and insulin granule fusion in INS-1 832/13 beta-cells exposed to glucotoxicity: partial restoration by glucagon-like peptide 1. Biochim Biophys Acta. 2016 Aug;1862(8):1401-11. (Abstract)

4/ Chavey A, Bailbé D, Maulny L, Renard JP, Movassat J, Portha B. A euglycaemic/non-diabetic perinatal environment does not alleviate early beta cell mal development and type 2 diabetes risk in the GK/Par rat model. Diabetologia. 2013, Jan;56(1):194-203. (Abstract)

5/ Figeac F, Ilias A, Bailbe D, Portha B, Movassat J. Local in vivo GSK3β knockdown promotes pancreatic β cell and acinar cell regeneration in 90% pancreatectomized rat. Mol Ther. 2012 Oct;20(10):1944-52. (Abstract)

Publications in peer-reviewed journals (since 2017)

** Publications shared with other teams of BFA.

Quartiles as from Scimago Journal & Country Rank are reported at the end of each publication.

Original articles

2023

Gong P, Bailbé D, Tolu S Pommier G, Liu J, Movassat J. Preconceptional exposure of adult male rats to bisphenol S impairs insulin sensitivity and glucose tolerance in their male offspring. Chemosphere 2022, 314:137691(Q1)

Delangre E, Pommier G, Tolu S, Uzan B, Bailbé D, Movassat J. Lithium treatment mitigates the diabetogenic effects of chronic cortico-therapy. Biomed Pharmacother. 2023 Aug;164:114895. (Q1)

Zhen D, Ding L, Wang B, Wang X, Hou Y, Ding W, Portha B, Liu J. Oral administration of kynurenic acid delays the onset of type 2 diabetes in Goto-Kakizaki rats. Heliyon. 2023 Jun 27;9(7):e17733. (Q1)

2022

Liu JJ, Bailbé D, Raynal S, Carbonne C, Zhen D, Dairou J, Gausseres B, Armanet M, Domet T, Pitasi C, Movassat J, Lim C, Guillemin G, Autier V, Kergoat M, Portha B. The tryptophan/kynurenine pathway is activated in the pancreatic endocrine cells by diabetes and its blockade improves glucose-induced insulin secretion. Biochim Biophys Acta Mol Basis Dis.  (11):166509 (Q1)

Motte-Signoret E, Saint-Martin C, Bellané-Chantelot C, Portha B, Boileau P. Glucocorticoid-induced hyperinsulinism in a preterm neonate with inherited ABCC8 variant. Metabolites. 2022 12(9):847 (Q2)

Sjöholm A, Corbett J, Leung PS, Portha B. Editorial: Understanding the gene expression of β-cell dysfunction in diabetes. Front. Endocrinol. 2022 13:1069991 (Q1)

A Holistic View of the Goto-Kakizaki Rat Immune System: Decreased Circulating Immune Markers in Non- Obese Type 2 Diabetes.  Seal SV, Henry M, Pajot C, Holuka C, Bailbé D, Movassat J, Darnaudéry M, Turner JD. Front Immunol. 2022, 13:896179. (Q1)

Mesto N, Bailbe D, Eskandar M, Pommier G, Gil S, Tolu S, Movassat J, Tourrel-Cuzin C. Involvement of P2Y signaling in the restoration of glucose-induced insulin exocytosis in pancreatic β cells exposed to glucotoxicity. J. Cell Physiol. 2022, 237(1):881-896. Epub 2021. (Q1)

2021

Delangre E, Liu J, Tolu S, Maouche K, Armanet M, Cattan P, Pommier G, Bailbé D, Movassat J. Underlying mechanisms of glucocorticoid-induced β-cell death and dysfunction: a new role for glycogen synthase kinase 3. Cell Death Dis. 2021, 12(12):1136. (Q1)

**Brookes O, Boland S, Lai Kuen R, Miremont D, Movassat J, Baeza-Squiban A Co-culture of type I and type II pneumocytes as a model of alveolar epithelium. PLoS One. 2021, 16(9):e0248798. (Q1)

Gong P, Bailbé D, Bianchi L, Pommier G, Liu J, Tolu S, Stathopoulou MG, Portha B, Grandjean V, Movassat J. Paternal High-Protein Diet Programs Offspring Insulin Sensitivity in a Sex-Specific Manner. Biomolecules. 2021, 11(5):751. (Q2)

Bailbe D, Liu J, Gong P, Portha B. Effect of Postnatal Nutritional Environment Due to Maternal Diabetes on Beta Cell Mass Programming and Glucose Intolerance Risk in Male and Female Offspring. Biomolecules. 2021, 11(2):179. (Q2)

**Bourgneuf C, Bailbé D, Lamazière A, Dupont C, Farabos D, Cohen-Tannoudji J, Monniaux D, Fève B, Movassat J, diClemente N, Racine C. The diabetic Goto-Kakizaki rat, the first spontaneous prototypical rodent model of the polycystic ovary syndrome. Nat Commun. 2021, 12(1):1064. (Q1)

Reger de Moura C, Landras A, Khayati F, Maskos U, Maouche K, Battistella M, Menashi S, Lebbé C, Mourah S. CD147 Promotes Tumor Lymphangiogenesis in Melanoma via PROX-1. Cancers (Basel). 2021, 13(19):4859. (Q1)

Fahy L, Calvo J, Chabi S, Haddad R, Poglio S, Leblanc T, Petit A, Baruchel A, Ballerini P, Naguibneva I, Arcangeli ML, Mazurier F, Pflumio F, Uzan B. Low O2 concentrations favor chemoresistance in T-ALL through HIF1a activation and mTORC1 inhibition. Blood Adv. 2021, 5(2):513-526. (Q1)

Nguyen TL, Nokin MJ, Terés S, Tomé M, Bodineau C, Galmar O, Pasquet JM, Rousseau B, van Liempd S, Falcon-Perez JM, Richard E, Muzotte E, Rezvani HR, Priault M, Bouchecareilh M, Redonnet-Vernhet I, Calvo J, Uzan B, Pflumio F, Fuentes P, Toribio ML, Khatib AM, Soubeyran P, Murdoch PDS, Durán RV. Downregulation of Glutamine Synthetase, not glutaminolysis, is responsible for glutamine addiction in Notch1-driven acute lymphoblastic leukemia. Mol Oncol. 2021, 15(5):1412-1431. (Q1)

Chabi S, Thi Hong Van To, Gonçalves PJ, Jaccard M, Petersson K, Petit B, Romeo PH, Pflumio F, Vozenin MC and Uzan B. Differential effect of FLASH radiotherapy on human T cell acute lymphoblastic leukemia and on human normal hematopoiesis. Int J Radiat Oncol Biol Phys. 2021. 109(3):819-829. (Q1)

Nguyen C, Mondoloni S, Le Borgne T, Centeno I, Come M, Jehl J, Solié C, Reynolds LM, Durand-de Cuttoli R, Tolu S, Valverde S, Didienne S, Hannesse B, Fiancette JF, Pons S, Maskos U, Deroche-Gamonet V, Dalkara D, Hardelin JP, Mourot A, Marti F, Faure P. Nicotine inhibits the VTA-to-amygdala dopamine pathway to promote anxiety. Neuron. 2021, 109: 2604-2615. (Q1)

2020

**Gausserès B, Liu J, Foppen E, Tourrel-Cuzin C, Rodriguez Sanchez-Archidona, Delangre E, Cruciani-Guglielmacci, Pons S, Maskos U, Thorens B, Magnan C, Movassat J, Maouche K. The Constitutive Lack of α7 Nicotinic Receptor Leads to Metabolic Disorders in Mouse. Biomolecules. 2020, 16;10(7):1057. (Q2)

Pitasi CL, Liu J, Gausserès B, Pommier G, Delangre E, Armanet M, Cattan P, Mégarbane B, Hanak AS, Maouche K, Bailbé D, Portha B, Movassat J. Implication of glycogen synthase kinase 3 in diabetes-associated islet inflammation. J Endocrinol. 2020, 244(1):133-148. (Q1)

Fagnan A, Bagger FO, Piqué-Borràs MR, Ignacimouttou C, Caulier A, Lopez C, Robert E, Uzan B, Gelsi-Boyer V, Aid Z, Thirant C, Moll U, Tauchmann S, Kurtovic-Kozaric A, Maciejewski JP, Dierks C, Spinelli O, Salmoiraghi S, Pabst T, Shimoda K, Deleuze V, Lapillonne H, Sweeney C, Mansat-De Mas V, Leite B, Kadri Z, Malinge S, de Botton S, Micol JB, Kile BT, Carmichael CL, Iacobucci I, Mullighan CG, Carroll MP, Valent P, Bernard OA, Delabesse E, Vyas P, Birnbaum D, Anguita E, Garcon L, Soler E, Schwaller J, Mercher T. Human erythroleukemia genetics and transcriptomes identify master transcription factors as functional disease drivers. Blood. 2020, 136(6):698-714. (Q1)

Berland C, Montalban E, Perrin E, Di Miceli M, Nakamura Y, Martinat M, Sullivan M, Davis XS, Shenasa MA, Martin C, Tolu S, Marti F, Caille S, Castel J, Perez S, Salinas CG, Morel C, Hecksher-Sørensen J, Cador M, Fioramonti X, Tschöp MH, Layé S, Venance L, Faure P, Hnasko TS, Small DM, Gangarossa G, Luquet SH. Circulating Triglycerides Gate Dopamine-Associated Behaviors through DRD2-Expressing Neurons. Cell Metabolism. 2020 31: 773-790. (Q1)

2019

**Movassat J, Delangre E, Liu J, Gu Y, Janel N. Hypothesis and Theory: Circulating Alzheimer’s-related biomarkers in type 2 diabetes. Insight from the Goto-Kakizaki rat. Front Neurol. 2019, 26;10:649. (Q1)

Filhoulaud G, Benhamed F, Pagesy P, Bonner C, Fardini Y, Ilias A, Movassat J, Burnol AF, Guilmeau S, Kerr-Conte J, Pattou F, Issad T, Postic C. O-GlcNacylation Links TxNIP to Inflammasome Activation in Pancreatic β Cells. Front Endocrinol (Lausanne). 2019, 10:291. (Q1)

**Latour A, Gu Y, Kassis N, Daubigney F, Colin C, Gausserès B, Middendorp S, Paul JL, Hindié V, Rain JC, Delabar JM, Yu E, Arbones M, Mallat M, Janel N. LPS-Induced Inflammation Abolishes the Effect of DYRK1A on IkB Stability in the Brain of Mice. Mol Neurobiol. 2019 Feb;56(2):963-975 (Q1)

2018

Mallek A, Movassat J, Ameddah S, Liu J, Semiane N, Khalkhal A, Dahmani Y. Experimental diabetes induced by streptozotocin in the desert gerbil Gerbillus gerbillus and the effects of short-term 20-hhydroxyecdysone administration. Biomed Pharmacother. 2018, 102:354-361. (Q1)

2017

Desrois M, Lan C, Movassat J, Bernard M. Reduced up-regulation of the nitric oxide pathway and impaired   endothelial and smooth muscle functions in the female type 2 diabetic goto-kakizaki rat heart Nutr Metab (Lond). 2017, 14:6. (Q1)

Purwana, I, Liu JJ, Portha B, Buteau J. HSF1 acetylation decreases its transcriptional activity and enhances glucolipotoxicity-induced apoptosis in rat and human beta cells. Diabetologia. 2017, 60(8):1432-1441. (Q1).

Reviews

**Hamzé R, Delangre E, Tolu S, Moreau M, Janel N, Bailbé D, Movassat J. Type 2 Diabetes Mellitus and Alzheimer’s Disease: Shared Molecular Mechanisms and Potential Common Therapeutic Targets. Int J Mol Sci. 2022 4;23(23):15287 (Q1)

Mesto N, Movassat J, Tourrel-Cuzin C. P2-type purinergic signaling in the regulation of pancreatic β-cell functional plasticity as a promising novel therapeutic approach for the treatment of type 2 diabetes? Front. Endocrinol. 2022 1099150 (Q1)

Uzan B, J. Movassat J. Rôle des macrophages dans l’inflammation insulaire au cours du diabète de type 2. Correspondances en Métabolismes Hormones Diabètes et Nutrition. 2022, N°6 – décembre 2022

Portha B. Burn-out de la cellule bêta pancréatique au cours du diabète de type 2. Quels mécanismes?. EMC Endocrinologie/Nutrition (2022).

**Moreau M, Benhaddou S, Dard R, Tolu S, Hamzé R, Vialard F, Movassat J, Janel N. Metabolic Diseases and Down Syndrome: How Are They Linked Together? Biomedicines. 2021, 9(2):221. (Q1)

Portha B, Grandjean V, Movassat J. Mother or father: who is in the front line? Mechanisms underlying the non-genomic transmission of obesity/diabetes via the maternal or the paternal line. Nutrients. 2019, 11(2):233. (Q1)

Liu JJ, Movassat J, Portha B. Emerging role of kynurenines in metabolic pathologies. Curr Opin Clin Nutr Metab Care. 2019, 22(1):82-90. (Q1)