Modeling of channels leading to the active site of cytochrome P450 3A4 (CYP3A4)

Edited by April 16, 2019


Communicated by the Computational  Modeling of Protein-Ligand Interactions Team

Cytochrome P450 3A4 (CYP3A4) is an enzyme located in the human liver. It has an important detoxification role and it catalyzes the oxidation of numerous xenobiotics. Modeling the channels leading to the active site of CYP3A4 provides a better understanding of its multispecificity.

Benkaidali, L; André, F; Moroy, G; Tangour, B; Maurel, F ; Petitjean, M. Four major channels detected in the cytochrome P450 3A4 : a stop toward understanding its multispecificity. Int. J. Mol. Sci. 2019, 20[4], 987. doi : 10.3390/ijms20040987

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