Toxicogenomic analysis to explore mechanisms of hepatic steatosis

Edited by April 9, 2019

Communicated by the Computational Modeling of Protein Ligand Interactions Team


Hepatic steatosis is a factor leading to nonalcoholic fatty liver disease (NAFLD). A toxicogenomic analysis based on 28 chemicals-induced hepatic steatosis have identified genes and pathways highly deregulated in a dose and time dependent manner.

Analysis of time-series gene expression data to explore mechanisms of chemical-induced hepatic steatosis toxicity. Aguayo-Orozco A., et al. Front. Genet. 2018, 9, 396